Lung Cancer Model Manufacturer,Supplier and Exporter in India
Product Code : JL-BE-5180
Jlab Export is a leading Lung Cancer Model Manufacturer,and suppliers in India, Lung Cancer Model Manufacturer,and suppliers in South Africa, Lung Cancer Model Algeria (Algiers), Lung Cancer Model Angola (Luanda), Lung Cancer Model Argentina (Buenos Aires), Lung Cancer Model Armenia (Yerevan), Lung Cancer Model Australia (Canberra), Lung Cancer Model Austria (Vienna), Bahrain (Manama), Bangladesh (Dhaka), Bhutan (Thimphu), Bolivia (Sucre), Botswana (Gaborone), Brazil (Brasília), Brunei (Bandar Seri Begawan), Montenegro (Podgorica), Morocco (Rabat), Mozambique (Maputo), Myanmar (Naypyidaw), Namibia (Windhoek), Nepal (Kathmandu), New Zealand (Wellington), Nigeria (Abuja), Oman (Muscat), Palestine (Ramallah), Panama (Panama City), Papua New Guinea (Port Moresby), Paraguay (Asunción), Peru (Lima), Philippines (Manila)¸ Portugal (Lisbon), Qatar (Doha), Rwanda (Kigali), Saudi Arabia (Riyadh), Senegal (Dakar), Serbia (Belgrade), Sierra Leone (Freetown), Slovakia (Bratislava), South Africa (Cape Town) (Pretoria) (Bloemfontein), South Sudan (Juba), Spain (Madrid), Sri Lanka (Sri Jayawardenepura Kotte) (Colombo), Sudan (Khartoum), Syria (Damascus), Tanzania (Dodoma), Thailand (Bangkok), Togo (Lomé), Tonga (Nuku'alofa), Trinidad and Tobago (Port of Spain), Tunisia (Tunis), Turkey (Ankara), Turkmenistan (Ashgabat), Uganda (Kampala), United Arab Emirates (Abu Dhabi), United Kingdom (London), United States (Washington, D.C.).
Lung Cancer Model
It arrests cell cycle in two ways.
1) As with fluorouracil and other analogues of pyrimidines, the triphosphate analogue of gemcitabine replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication.
The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis.
2) Another target of gemcitabine is the enzyme ribonucleotide reductase (RNR).
The diphosphate analogue binds to RNR active site and inactivates the enzyme irreversibly.
Once RNR is inhibited, the cell cannot produce the deoxyribonucleotides required for DNA replication and repair, and cell apoptosis is induced.
Gemcitabine is widely used in the treatment of cancers and has shown activity against a variety of solid tumours, including pancreatic, breast, bladder, ovarion and non-small cell lung cancer.
Notable effect of the treatment is observed when Gemcitabine is used in combination with Carboplatin.
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