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Malignant Nephrosclerosis, Flea Bitten Kidney Model

May see narcotizing glomerulitis, wrinkling and collapse of capillary walls and small crescents.

Myointimal hyperplasia and hypertrophy is associated with acute or persistent severe high blood pressure.

Fibroid necrosis of arterioles, hyper plastic arterioles(onion skinning) due to concentric layering of collagen.

Necrotizing arteriolitis:-

Fibrinoid necrosis of afferent arteriole, often superimposed on hyperplastic or hyaline lesions; media has deposits of deeply eosinophilic and fibrillar material containing fibrin and fibrinogen.

Early changes:-

Profound intimal thickening by myxoid connective tissue, reducing lumen.

Late changes:-

Scarring and concentric thickening of vessel wall by myointimal cells and deposition of basement membrane type material (onion skinning).

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